Motif Bio Plc
MTFB:LN
Overview
Company Profile
Motif Bio plc (AIM:MTFB) (NASDAQ:MTFB) is a clinical-stage biopharmaceutical company focused on developing novel antibiotics for hospitalised patients and designed to be effective against serious and life-threatening infections caused by multi-drug resistant bacteria, including MRSA. The Company’s lead product candidate is iclaprim. Following positive results from two Phase 3 trials (REVIVE-1 and REVIVE-2), an NDA has been submitted to the U.S. FDA for the treatment of acute bacterial skin and skin structure infections (ABSSSI). More than 3.6 million patients with ABSSSI are hospitalised annually in the U.S. It is estimated that up to 26% of hospitalized ABSSSI patients have renal impairment. The Company believes, based on the data from the Phase 3 REVIVE studies, that iclaprim may be suitable for first-line empiric therapy in ABSSSI patients, including those with renal impairment, with or without diabetes.
The Company also plans to develop iclaprim for hospital acquired bacterial pneumonia (HABP), including ventilator associated bacterial pneumonia (VABP), as there is a high unmet need for new therapies in this indication. A Phase 2 trial in patients with HABP has been successfully completed and a Phase 3 trial is being planned. Additionally, iclaprim has been granted orphan drug designation by the FDA for the treatment of Staphylococcus aureus lung infections in patients with cystic fibrosis and is in preclinical development for this indication.
Iclaprim has received Qualified Infectious Disease Product (QIDP) designation from the FDA together with Fast Track status. Upon acceptance by the FDA of an NDA, iclaprim will receive Priority Review status and, if approved as a New Chemical Entity, will be eligible for 10 years of market exclusivity in the U.S. from the date of first approval, under the Generating Antibiotic Incentives Now Act (the GAIN Act). In Europe, 10 years of market exclusivity is anticipated.
Classification
Sector Finance
Industry Diversified Financial Services
Subindustry Other Diversified Financial Services
Financials
Corporate
Board of Directors
Richard C.E. Morgan
Chairman
Richard C.E. Morgan is Chief Executive Officer of Amphion Innovations plc. Over the course of his career, Mr. Morgan has been directly involved in the start-up and development of more than 35 companies in the information technology, healthcare, and biotechnology industries. Mr. Morgan was a founder and Chief Executive Officer of Amphion Capital Partners LLC (the predecessor company). He was also the Managing General Partner of Amphion Partners LLC (formerly known as Wolfensohn Partners, LP) a position which he retains, although the partnership is no longer active. Before joining Wolfensohn, Mr. Morgan spent 15 years with Schroders plc, a British merchant bank, where he was a member of the Board of the merchant bank and head of the Schroder Strategy Group, which he founded. Mr. Morgan, a British citizen, was raised in Kenya and educated in England. He graduated with a B. Engineering First Class Honors from the University of Auckland, New Zealand. In 1982 he completed the Advanced Management Program at the Harvard Business School. He is currently also Chairman of Axcess International, Inc., FireStar Software Inc., PrivateMarkets, Inc., and WellGen, Inc.
Graham Lumsden
Chief Executive Officer, Director
Graham Lumsden, Chief Executive Officer of Motif, is responsible for all aspects of the strategy, management, and operations of the Company. Prior to joining Motif, Mr. Lumsden was Worldwide Business Leader, Contraceptives and Osteoporosis at Merck & Co., Inc. where he previously held other international senior leadership roles as well as senior marketing positions. Mr. Lumsden has a proven record of success leading change and delivering results at Worldwide Vice President level including cross-functional team leadership, new product launches, pre-clinical / clinical development, regulatory strategy, IP strategy / litigation, and domestic / international sales and marketing. Mr. Lumsden is a member of the Royal College of Veterinary Surgeons (MRCVS), holds a masters from the Chartered Institute of Marketing (MCIM), and is a dual citizen of the U.S. and UK.
Bruce Williams
Non-Executive Director
Bruce Williams has significant operational experience in the Pharmaceutical and Biotech industries. Mr Williams was an executive director of Ortho Biotech where he led the marketing of this Johnson & Johnson subsidiary’s lead product Procrit (epoetin alfa) from pre-launch through to its first year on the market, realizing $1 billion of revenue. Mr Williams was previously senior vice president of sales and marketing at Celgene Corporation where he built the company’s commercial and distribution infrastructure to support the launch of its first product Thalomid (thalidomide). Mr Williams was previously senior vice president, Sales and Marketing at Genta Incorporated where he lead the negotiaton of a licensing and co-development/co-marketing agreement with Aventis for the company’s lead product. The company realized over $300 million in proceeds from this agreement. Mr Williams currently serves on the boards of Motif and Afaxys Incorporated. He also Chairs the Board of Trustees of Rutgers Preparatory School, New Jersey’s first independent school.
Mary Lake Polan, M.D, Ph.D, MPH
Non-Executive Director
Mary Lake Polan, M.D., Ph.D., M.P.H., is a Clinical Professor in the Department of Obstetrics, Gynecology and Reproductive Sciences at Yale University School of Medicine. Dr. Polan specializes in reproductive endocrinology and infertility and hormonal issues related to gynecology patients and menopause. She received her bachelor’s degree from Connecticut College and her Ph.D. in Molecular Biophysics and Biochemistry and M.D. from Yale University and completed her residency and Reproductive Endocrine Fellowship in the Department of Obstetrics and Gynecology at the Yale University School of Medicine. Dr. Polan received her M.P.H. (Maternal and Child Health Programme) from the University of California, Berkeley. Dr. Polan served on the board of Wyeth Pharmaceuticals prior to its acquisition by Pfizer and currently serves on the board of Quidel Corp, San Diego, CA and on the boards of several privately held life sciences companies. She chairs an SAB in Women’s Health for the Proctor and Gamble Company and several other advisory boards of private life sciences companies. She is also a Managing Director of Golden Seeds, an angel investing group which invests in women led companies.
Zaki Hosny
Non-Executive Director
Zaki Hosny is an independent consultant to life sciences companies. Mr. Hosny spent most of his career at Merck & Co in marketing and general management positions around the globe, including management responsibility for the company’s business in major markets in Europe. Mr. Hosny also held senior marketing roles with worldwide responsibility for cardiovascular and other franchises, and was closely involved in the clinical development of some of the company’s major products. Mr. Hosny was Chief Executive Officer of Motif from 2006-13, and Deputy Chairman of its Board of Directors. Mr. Hosny is currently a Senior Advisor to the Albright Stonebridge Group, a strategic consultancy firm based in Washington, DC; Business Development Advisor to ClinTec International, a contract research organisation based in Glasgow, Scotland; and a consultant to Harel Consulting of New Jersey, and Mettle Consulting of the UK. Mr. Hosny is based in Princeton, NJ and is a graduate of Cambridge University with an MA in history and law.
Charlotta Ginman
Non-Executive Director
Charlotta Ginman has substantial experience in financial and operational management gained during her career in investment banking and global telecommunications. Joining Ernst & Young and later appointed to senior roles with JP Morgan, Deutsche Bank and UBS, Ms. Ginman progressed to director of finance at Nokia Corporation, overseeing a number of acquisitions and led the successful sale of Nokia’s luxury mobile phone division, Vertu Corporation, to a private equity group. During the last two years she has been appointed as a non-executive director onto the boards of Wolfson Microelectronics plc (until its sale to Cirrus Logic in Aug 2014), Kromek Group plc where she also acts as chair of the audit committee as well as onto the board of Pacific Assets Trust plc, all UK based listed companies. A qualified chartered accountant in England and Wales, Ms. Ginman also holds an MSc in Economics from the Swedish School of Economics and Business Administration in Helsinki.
Craig T. Albanese
Non-Executive Director
Craig T. Albanese, M.D., M.B.A., is the Senior Vice President and Chief Operating Officer, New York-Presbyterian/Morgan Stanley Children’s Hospital and Sloane Hospital for Women. Dr. Albanese is responsible for overseeing all operations and managing the strategic direction of the children’s and women’s hospital. He has spent the last 15 years in various leadership positions in healthcare. Prior to his position at New York Presbyterian (NYP), he spent 14 years at Stanford Children’s Health, most recently serving as the Vice President of Quality and Performance Improvement. He also served as the John A. and Cynthia Fry Gunn Director of Pediatric Surgical Services at Lucile Packard Children’s Hospital, and was a Professor of Surgery, Pediatrics, and Obstetrics and Gynecology at Stanford University Medical Center. Prior to this, Dr. Albanese held faculty appointments and leadership roles at the Children’s Hospital of Pittsburgh and the University of California, San Francisco. After receiving his medical degree from SUNY Health Science Center in Brooklyn, Dr. Albanese was a resident and chief resident in general surgery at Mount Sinai Medical Center. He then completed pediatric general surgery and critical care research fellowships at Children’s Hospital of Pittsburgh. Dr. Albanese also holds a Master’s in Business Administration from the Leavey School of Business at Santa Clara University. He has published more than 160 peer reviewed articles, was an NIH-funded investigator, and the program director for Stanford’s pediatric general surgery fellowship. An expert in management and improvement science and operations, he published a best-selling book on improvement science in health care entitled, “Advanced Lean in Healthcare. His recent work at NYP has been aimed at implementing a daily management system across NYP’s 6 hospitals. Dr. Albanese is also the executive sponsor for Graduate Medical Education at NYP, the nation’s largest single site training program.
Jonathan E. Gold
Interim Chief Financial Officer
Mr. Gold has a history of senior financial positions and is currently Managing Director of JEG Capital Partners LLC, a family office and asset manager. He previously was a portfolio manager for the Federated Kaufmann Funds. Prior to that, Mr. Gold was a venture capitalist and was active in financing and building life sciences and technology companies. Mr. Gold received his B.S. and MBA in Finance from New York University’s Stern School of Business.