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Poolbeg Pharma moves closer to obtaining US patent for flagship asset POLB 001

09:24, 20th March 2024
Victor Parker
Vox Newswire

Poolbeg Pharma (POLBFollow | POLB, a clinical-stage biopharma company focused on infectious diseases, said it has received a Notice of Allowance from the US Patent Office in relation to its Immunomodulator II patent application. A Notice of Allowance is a precursor to a formal grant of a patent.

The claims cover a class of drugs, including POLB 001 - Poolbeg's flagship anti-inflammatory candidate - for the treatment and prevention of cytokine storm (hypercytokinaemia) after an immune response has been triggered. This encompasses cytokine storm induced in any disease indication.

The patent in progress marks a significant step for POLB 001, a potent and selective Phase II-ready p38 MAP kinase inhibitor (mitogen-activated protein kinase) which has shown strong potential across multiple disease areas. In November, Poolbeg was granted a similar patent for Immunomodulator II in Japan.


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The Notice of Allowance from the US Patent Office represents a significant milestone for Poolbeg as it continues to build its IP portfolio. The company has a global license for POLB 001 and is actively building a comprehensive portfolio with patents in place, including Immunomodulator I and II, covering the use of the class of p38 MAP inhibitors for the treatment of severe influenza, and the use of POLB 001 for the treatment of hypercytokinaemia.

Today's announcement further highlights the progress Poolbeg has made in developing its patent portfolio, enhancing the value and attractiveness of its lead asset POLB 001 to potential pharma partners, particularly in respect of cancer immunotherapies. In response to the news, investors sent POLB shares 6.04% higher in early trade on Wednesday.

POLB 001 has strong potential in making cancer immunotherapies more accessible by enabling their safer and broader use in an outpatient setting. The candidate has a compelling data package and targets unmet medical needs across several disease areas. POLB 001's potential to treat cancer immunotherapy-induced Cytokine Release Syndrome (CRS) alone has a market potential of US$10bn.

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