Vox Markets Logo

Avacta's AVA6000 makes waves in oncology with promising Phase 1a trial

09:50, 21st March 2024
Paul Hill
PMH Capital

The best things in life are worth waiting for. Indeed, for Avacta (AVCTFollow | AVCT - a 'smart chemo' diagnostics and drug development firm - the R&D news seems to get better and better.

Today the company reported outstanding safety data for its lead AVA6000 therapeutic (albeit from a relatively small patient size) in a 3-week dosing Phase 1a trial across 7 cohorts - the last one being conducted at a concentration 3.5x greater than standard doxorubicin.

It had recently commenced US testing of AVA6000 in a new fortnightly dose escalation study (1.45x concentration) in order to see whether this shorter cycle time improves efficacy without impacting toxicity. Regulatory approval has also been granted in the UK with 1st data from Cohort 1 hopefully being available by the end of April.

Either way, the combined 2 and 3 week studies will be used to help design a potentially pivotal Phase II trial planned for late 2024.

CEO Alastair Smith commenting: "We are extremely pleased with the continued excellent progress of AVA6000 in the Phase 1a dose escalation study. These emerging data clearly demonstrate that the preCISION platform is functioning in the way it was designed, and is capable of targeting the release of a cancer therapy to the tumor. Targeted therapy that spares healthy tissues is a holy grail of oncology drug development and we believe we have a unique platform to target FAP-rich tumor tissues to deliver significantly better outcomes for patients and substantial value to our shareholders."

"We are looking forward to providing a further detailed update on the clinical trial at the American Association for Cancer Research meeting in April."

Elsewhere, AVCT’s next candidate AVA3996, a FAP-activated proteasome inhibitor, is slated to enter clinical trials in 2024/25, adding another possible multi $bn per year addressable market to the drug pipeline.

And there are plenty of other exciting 3rd party licensing agreements (e.g. with LG Chem, POINT Biopharma, a wholly-owned subsidiary of Eli Lilly and Company and AffyXell Therapeutics), alongside a fast growing European diagnostics arm and a high-potential Affimer therapeutic platform.

Finally, in terms of commercialisation - whilst Avacta intends to have an active in-house clinical development team for its own assets (e.g. AVA6000), I believe it would consider partnering with Big Pharma for larger Phase 3 trials, and may also have nearer-term options with regards to licensing out preCISION's FAP activated tech to other 3rd parties.

Stock Chart | AVCT

Follow News & Updates from Avacta: Follow | AVCT


Disclaimer & Declaration of Interest

The information, investment views and recommendations in this article are provided for general information purposes only. Nothing in this article should be construed as a solicitation to buy or sell any financial product relating to any companies under discussion or to engage in or refrain from doing so or engaging in any other transaction. Any opinions or comments are made to the best of the knowledge and belief of the writer but no responsibility is accepted for actions based on such opinions or comments. Vox Markets may receive payment from companies mentioned for enhanced profiling or publication presence. The writer may or may not hold investments in the companies under discussion.

Recent Articles